Men’s Hormone Health
TRT vs. Enclomiphene: What’s the Difference?
Testosterone replacement and enclomiphene work in very different ways. Here is how they compare, and the factors a provider typically weighs.
7 min readRead More
Education
Fertility
Can Testosterone Therapy Affect Fertility?
What men planning a family should know before starting treatment.
6 min readPublished September 15, 2026Medically reviewed by: Licensed Medical Provider
Fertility is one of the most important — and most overlooked — topics in testosterone care.
Why TRT can affect sperm production
When testosterone is supplied from outside, the brain may reduce the signals that tell the testes to produce testosterone and sperm. For some men this can reduce fertility while on treatment.
“If a family is part of your plans, say so at your very first visit.”
Alternatives often discussed
Enclomiphene works by supporting the body’s own signaling, which is why it is often discussed for men who want to maintain fertility. See our enclomiphene overview.
Medical Disclaimer
This content is provided for educational purposes only and is not intended to diagnose, treat, cure, or prevent any medical condition. Individual treatment decisions should be made with a licensed medical provider based on your medical history, symptoms, laboratory results, risk factors, and other relevant information.
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